One of the most unusual settings I've seen recently, with the pavilion of the outer stones providing a backdrop for the main, inner stone. The piece, named Coupelle Piége (cup trap, or the like), is from the Architecte collection by Lorenz Baümer (featured before) and consists of a tourmaline (central stone), fire opals and Citrines (the stones in the side, and small diamonds set in 18kt rose gold. There is red Spinel somewhere in the piece, according to his website, but I'm not sure where.
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NB: His website uses some heavy flash and is not safe for those who sudder from vertigo
A little gaudy (and oversized for a ring), but I actually find this one rather pretty...
I really like that one. I'm not sure it'd look good on a hand, but as a work of art it's very compelling.